United, Europa League semifinalists last season, reached the last eight after Paul Pogba’s goal saw them beat AC Milan 1-0 at San Siro and face Granada, who are in the quarterfinals first time. The La Liga side reached this stage with a stunning win over Napoli before beating Molde in the round of 16.
Arsenal is looking to go one better than 2019 when they were beaten finalists but will have to overcome a Slavia side who have so far eliminated Leicester City and Scottish champions Rangers.
Villarreal boss Unai Emery, who won this competition in three consecutive years with Sevilla, is bidding to become the first manager to win a European competition on four occasions. They will face Dinamo, who reached the last eight after a stunning comeback victory over Tottenham Hotspur in the round of 16.
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Granada vs Manchester United
Arsenal vs Slavia Prague
Ajax vs Roma
Dinamo Zagreb vs Villarreal
Games will be played across two legs on Thursday April 8 and Thursday April 15, 2021.